The immune modulator transforming chronic care

Restore your body's balance with low dose naltrexone

Low dose naltrexone (LDN) is a clinically studied therapy that helps regulate immune activity, reduce inflammation, and support mood and brain health. Our personalized LDN protocols are designed to enhance your well-being, improve mental clarity, and help you manage chronic symptoms without using harsh immunosuppressants.

Low dose naltrexone clinic
Balances immune function
Reduces inflammation and pain
Supports mood and brain health
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Over 8,000 patients treated
Low dose naltrexone clinic
Personalized support
Local clinics
No hidden fees
LegitScript-certified
Third-party tested
Made in the USA
Man running with less inflammation from LDN therapy
How does low dose naltrexone work?

LDN helps rebalance the immune system without suppressing it

Low dose naltrexone (LDN) functions by temporarily blocking opioid receptors, which triggers an increase in endorphin production. This process helps to rebalance the immune system. Unlike traditional immunosuppressants that diminish immune response, LDN regulates it, making it an effective option for managing chronic pain, autoimmune disorders, and neuroinflammation.

Benefits of low dose naltrexone

LDN therapy is recognized for enhancing quality of life in various chronic inflammatory and autoimmune conditions.
Reduces chronic pain
Modulates immune function
Decreases inflammation
Improves sleep quality
Enhances mood stability
Boosts energy levels
Personalized LDN medication

Who is low dose naltrexone for?

Autoimmune conditions: For individuals looking for alternatives to support their treatment plan
Chronic pain sufferers: For conditions such as fibromyalgia and chronic fatigue, as well as pain that does not respond to traditional medications
Inflammatory conditions: For long COVID, mast cell issues, or unexplained chronic inflammation
Cancer support: May help reduce tumor burden and improve quality of life during treatment
Mental health: For treatment-resistant depression, anxiety, or PTSD linked to immune-mood dysregulation
LDN must be prescribed and dosed by qualified LDN doctors after a thorough evaluation.
Who is LDN therapy for
Low dose naltrexone pricing
For inflammation, pain, and autoimmunity

Low dose naltrexone pricing

In stock | Reduce inflammation
Pharmaceutical-grade, full-strength formula
Oral delivery available
Purity and lab tested
Dispensed by a LegitScript-certified facility
12-month
20% Off
$39.20
Billed every 12 months. Shipped monthly
Save
$9.80 per month
6-month
15% Off
$41.65
Billed every 6 months. Shipped monthly
Save
$7.33 per month
3-month
10% Off
$44.10
Billed every 3 months. Shipped monthly
Save
$4.90 per month
Monthly
$49.00
Billed and shipped monthly

Hit your health goals in
4 simple steps

Friendly NAD⁺ specialist

Quick online intake

Answer a few questions about your health and goals.
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Clinical consultation

Review diagnostic labs and a personalized plan.
start your customized longevity protocol

Start your protocol

Begin treatment in-clinic or at home (if eligible).
get ongoing optimization help and feedback

Ongoing optimization

We track progress and adjust your plan as needed.

Hit your health goals in
4 simple steps

Friendly NAD⁺ specialist

Quick online intake

Answer a few questions about your health and goals.
Smiling woman texting

Clinical consultation

Review diagnostic labs and a personalized plan.
start your customized longevity protocol

Start your protocol

Begin treatment in-clinic or at home (if eligible).
get ongoing optimization help and feedback

Ongoing optimization

We track progress and adjust your plan as needed.

Expert answers to our most frequently asked questions

Low-dose naltrexone is a medication used off-label to help regulate immune function and reduce inflammation. It works by temporarily blocking opioid receptors, stimulating the body to produce more endorphins, which improves immune balance and reduces chronic symptoms.

LDN blocks opioid receptors briefly, triggering a rebound increase in natural endorphins. These endorphins help regulate immune activity, reduce inflammation, and improve pain and mood symptoms over time.

LDN has been shown to reduce pain, fatigue, and inflammation in patients with autoimmune, neurological, and inflammatory disorders. It may also improve sleep, cognitive function, and emotional well-being.

Avoid opioid pain medications, as LDN blocks their effect. Also, avoid alcohol and coordinate with your provider before combining with SSRIs, antihistamines, or immunosuppressants.

Some patients feel improvement in sleep and energy within 1–2 weeks. Pain and autoimmune symptom relief may take 4–12 weeks. Full benefits may take 3–6 months of consistent use.

LDN is compounded and often prescribed off-label, so insurance may not cover it. However, our office can provide itemized receipts for potential reimbursement or HSA use.

Weight gain is not a known side effect. In fact, many patients report reduced inflammation and improved energy that supports healthy metabolism and weight stability.

LDN can be taken long-term and is considered safe for extended use under medical supervision. Many patients stay on it for months or years depending on their condition and goals.

Yes. Side effects are typically mild and may include vivid dreams or sleep changes early on. LDN does not suppress immunity or carry the same risks as immunosuppressive medications.

Yes. LDN is often used alongside supplements, hormone therapy, or lifestyle interventions. Your provider will ensure it’s safe with your full protocol.

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Personalized plans by clinical experts
In-depth diagnostic testing before treatment begins
Ongoing support for lasting results
No insurance required

We start with advanced testing, turn your data into a personalized plan, and track progress to keep you improving.

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Over 8,000 patients treated
iThriveMD Receptionist Staff
Personalized support
Local clinics
No hidden fees
LegitScript-certified
Third-party tested
Made in the USA

Patient testimonials

Discover how our patients achieved success with our support. Explore their inspiring stories to see the potential outcomes we can help you achieve.

“I’ve lost 31 pounds, and my sleep is fantastic!”

Waynes testimonial
Wayne’s Story

Love the staff and all the amazing encouragement and most definitely the results of the weight loss medication!

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Kim W.

The Doctors here are very knowledgeable and friendly. I have been comming here for 5 months and have had such amazing weight loss! I highly recommend I Thrive MD.

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Alicia M.

They are very good at explaining & guiding me in the direction I should go with procedures without “selling”, which I super appreciate.

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Jennifer M.

I had my first visit at IThrive Encinitas and I am happy I did! The facility was well maintained, clean and bright and as soon as I arrived I was greeted by 2 very polite and professional Receptionists.

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Sheena H.

The Dr was very thorough and patiently answered all my questions. My first visit was awesome!

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Marina C.

I couldn’t be more thankful for iThriveMD! Since I started my journey mid October I’ve lost 25 pounds and feel like a new person! I have way more energy and don’t feel uncomfortable in my own skin anymore.

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Angelica H.

Their new wellness center in Mission Valley is awesome! So calming and comfortable from the moment you walk in.

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Holly G.

I have been coming to iThriveMD ever since they opened up and I am obsessed! This is like my new wellness place that I enjoy coming to when I am feeling down and need to be lifted up!

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Ari P.

I’ve been on it for 3 months and lost35 pounds. Fortunately I had no negative side effects. I feel great. Everyone here was very polite and very welcoming.

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Dr. Charles

Great location! Exceptional staff! I truly feel taken care of here! 10/10 recommend.

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